The Jackson Laboratory PDX Models
Point of Contact: Debra M. Krupke, MS; Dale A. Begley, PhD, http://www.informatics.jax.org/mgihome/support/mgi_inbox.shtml
Data Repository
Patient-Derived Xenografts (PDX) are generated through the engraftment and passaging of tissue or cells from a patient's tumor into an immunodeficient or humanized mouse host. PDX models are an in vivo platform for cancer biology research and for pre-clinical testing of cancer drug efficacy. The Mouse Models of Human Cancer Database provides access to information on hundreds of PDX models distributed by The Jackson Laboratory (JAX). Researchers can search for JAX PDXs by such criteria as primary cancer site, diagnosis, genomic characteristics of engrafted tumors, and PDX dosing study results.
Resource Description
Resource Type
Data Repository
Specialization
Mixed Adult and Pediatric
Data Update Date
04/12/2024
Data Content Type
Clinical, Genomics/Omics, Xenograft
Resource Tools
Visualization Tools
Analytic Tools
YES
Data Access
Case Disease Diagnosis
Acute Lymphocytic Leukemia (1); Adenocarcinoma (1); Alveolar Rhabdomyosarcoma (10); B-Cell Adult Acute Lymphocytic Leukemia (3); Brain Glioma (2); Colon Adenocarcinoma (2); Colon Carcinoma (1); Embryonal Rhabdomyosarcoma (1); Epithelioid Sarcoma (1); Ewing Sarcoma (1) ...
Number of Cases
56
Case Sex
Female (25); Male (30); Other (1)
Case Age At Diagnosis
0 to 4 years (6); 5 to 9 years (9); 10 to 14 years (10); 15 to 19 years (1); 20 to 24 years (11); 25 to 29 years (1); 30 to 34 years (6); 35 to 39 years (12)
Published In
Xenograft